By the 16th century at least, Chinese physicians had people inhale dried smallpox scabs to trigger a mild case and gain immunity. 'Variolation' was also practiced in India and the Ottoman Empire, where Lady Mary Wortley Montagu observed it before promoting it in England in 1721, 75 years before Jenner's vaccine.
Around 2300 BCE, Enheduanna, daughter of King Sargon of Akkad, became high priestess of the Moon god at Ur. She composed hymns to the goddess Inanna and put her name to them. She is the oldest person identified as the author of a literary work, about 1,500 years before Homer.
Squeeze Earth's 4.5 billion years into a single 24-hour day. Homo sapiens shows up around 11:59:54 p.m., roughly six seconds before midnight. All of written history, from Sumerian tablets to today, fits into the final tenth of a second. A cosmic blink.